1. Enedina Arellano Felix
Enedina Arellano Felix, also known as La Jefa , is one of the last standing female drug lord. She was the sister of the famous Arellano Felix brothers, a drug trafficking clan that operated in Tijuana. After the seven of male leading members of the cartel were dead or in prison, Enedina took over. Tijuana Cartel that she took over is in the business of trafficking heroin, cocaine, meth and marijuana in the USA. When her brothers were running the business , she studied accounting and used that knowledge for money laundering for her brothers. She is known for being less brutal and sadistic that her brothers, focusing more on business than at drug wars.